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Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig

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Although still debatable, evidence has pointed to a potential link between exposures to chemical contaminants and neurological disorders/mental illness, such as autism (Landrigan, 2010), Parkinsons disease (Barlow et al., 2007), Alzheimers disease (Coppede and Migliore, 2010), amyotrophic lateral sclerosis (Johnson and Atchison, 2009), just to name a few