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10.1021/ic402341n 43 CyrusK.WangQ.SharawiZ.NoguchiG.KaushalM.ChangT.et al (2021)

Clinically, this results in increased blood pressure and heart rate due to unopposed sympathetic stimulation

It achieves this by controlling the expression of pluripotency genes through the regulation of GSH homeostasis and the suppression of the mesoderm-inducing protein Brachyury ( The significance of CHAC2-NRF2 signaling pathway extends beyond development

It protects our DNA, cell lipids, and proteins from free radicals and oxidative stress

The sequence homology, structure and half-site occupancy imply that the protein is a [zeta]-class glutathione S-transferase, a maleylacetoacetate isomerase (MAAI)