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In addition to oxidative stress cytotoxicity, pyocyanin pathogenicity has shown to alter calcium homeostasis and depleting intracellular cAMP and ATP levels (Chakravarthi et al., 2006), alters human protease activity, modulates the host immune response to support evasion of the host immune system and establish chronic infection (Winstanley and Fothergill, 2008)

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