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Important safety considerations include: it is not recommended during pregnancy or breastfeeding

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Heinecke, JW Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase Circ Res 114 11: 1733-42

VinikAIBrilVKemplerPLitchyWJTesfayeSPriceKLet alTreatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial