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522 Combination strategies enhance ROS sensitivity through metabolic intervention

Together with their antioxidant roles against reactive oxygen species (ROS) and reactive nitrogen species (RNS), NAC and HPN-07whose structural analog is -phenyl-N-tert-butylnitrone (PBN)have each been reported to promote neurogenesis through proposed mechanisms involving the activation of the Rasextracellular signal-regulated kinase (ERK) and protein kinase C (PKC) pathways 30,31,32

BO International, 884, Udyog Vihar Haryana 122016

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Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT: Mu-opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization