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As COX17 serves as a primary copper donor in the IMS, 83 mutations in COX17 can reduce CCO activity and cause mitochondrial dysfunction and oxidative stress, 84 further supporting coppers significance in mitochondria

doi: 10.1016/j.semcdb.2021.01.005, 89 JingR.MuL.WangC.LiuL.WangY.WangY.et al

In contrast, prolonged OHP exposure to DRG neurons significantly increases T- and L-type Ca v channel currents

Pain increases a few hours after or the day after an activity such as a run How do you diagnose a TFCC injury

Later, another study showed that a Parthenolide (PTL)-derived drug DMOCPTL directly bound to the GPX4 active site (selenocysteine 46), and led to GPX4 ubiquitination in triple-negative breast cancer cells (Ding et al., 2021)