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In a trial on adult volunteers, this dose did not lead to a significant increase in serum vitamin B 12 levels when given thrice daily for one week
Cell 99 , 451454 (1999)
This effect on heart rate is an important safety issue that needs special attention in future trials since obese individuals are at increased cardiovascular risk
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those continuing on semaglutide 2.4 mg achieved a 7.9% BW reduction at study end, while patients on placebo exhibited a BW gain of 6.9% 25
