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10.1200/JCO.19.02492 275 TeperinoR.SchoonjansK.AuwerxJ

Improving the integrity of this barrier is critical to minimizing inflammatory responses

It also supports healthy inflammatory balance through multiple pathways. 25 Vitamin C supports histamine degradation and may support a healthy response to oxidative stress from the inflammatory response. 26 Bromelain (from pineapple) is a protein-digesting enzyme that enhances quercetin absorption and has its own properties that support a healthy inflammatory response. 27 Quercetin isn't well absorbed on its own, so the bromelain is particularly important

It directly binds the 3-UTR of SLC7A11 , reducing cystine uptake and GSH synthesis

[DOI] [PMC free article] [PubMed] [Google Scholar] Bishop, G