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To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig
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The STEP 5 trial provided 104-week data showing sustained efficacy
Changes in brain glutamate on switching to clozapine in treatment-resistant schizophrenia
Table 2 Examples of naturally derived biopolymers (NDBs) and their antibacterial performance
