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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

Characteristic symptoms of vitamin C deficiency include: swollen and bleeding gums fatigue poor wound healing joint pain loose teeth colored spots on the skin In some cases, signs of scurvy can occur within a month of consuming less than 10 milligrams (mg) per day of vitamin C

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The remainder of the studies included in this systematic review were observational studies or non-randomised interventional studies, which inherently have a high risk of bias