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Many people take L-carnitine supplements for various reasons, including supporting athletic performance, weight management, and cardiovascular health, though the evidence for these benefits varies

These discrepancies may be explained by the hypothesis that L-carnitine supplementation accompanied by high amounts of carbohydrate intake increases skeletal muscle OCTN2 expression through an insulin-mediated mechanism, thereby increasing skeletal muscle carnitine content [28, 29]

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Most clinical studies have examined these substances independently rather than in combination, so the safety profile and potential synergistic or additive effects remain inadequately characterised

A dosage adjustment may be necessary