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However, the duration of the hormone signal is short, as cAMP is quickly deactivated by the enzyme phosphodiesterase (PDE) , which is located in the cytosol
Total Neoadjuvant Therapy approach: A Shifting Paradigm in Locally Advanced Rectal Cancer

Children with this growth pattern establish a growth trajectory at or below the 5th percentile for length early in life but maintain a normal growth velocity and have a bone age matching their chronological age
A.HawkinsJ.PolingH

Fadilah NIM, Maarof M, Motta A, Tabata Y, Fauzi MB
