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Description
The recent demonstration of the importance of oxidative stress in osteoarthritis places the use of intra-articular antioxidants, namely glutathione and its precursor, as an important interventional strategy for both joint preparation for biologic therapies as well as a powerful ally in viscosupplementation

Petersburg, Florida: StatPearls Publishing

They are signaling molecules
Infections, medication, and other conditions can cause it, too
Additionally, these results can last for months or even years, depending on how well you maintain your diet and exercise routine after treatment