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Mayo, K.E., Hammer, R.E., Swanson, L.W., Brinster, R.L., Rosenfeld, M.G., Evans, R.M

Dissecting the extent of oxidation and reduction of disulfides is an ongoing challenge due, in part, to the facility of thiol/disulfide exchange reactions

PAE is an increasingly used treatment option for the management of lower urinary tract symptoms associated with prostate enlargement (BPH)

As a result, clinical scientists rely on historical data to define the dosing regimen of FIH studies, which is especially problematic for molecular entities with innovative formats

In contrast, NAC, bearing a negative charge at physiological pH, demonstrates slower cellular uptake due to its N-acetyl group, which hinders both passive and active membrane transport