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Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al
Moreover, synbiotics have been reported to improve gut integrity via SCFA production, by which inhibiting the TLR4LPS complex-triggered proinflammatory cascade, hampering proinflammatory cytokine signaling pathways, such as nuclear factor kappa B (NF-B), thereby decreasing insulin resistance (34)
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Challenges with combining molecularly target agents, Clinical Trial Design: Part 2: Clinical Trials Issues with Molecularly Targeted Agents, US
doi: 10.1038/s41525-020-00141-0 14
