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Description
Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

Extended karapandzic flaps for near-total and total lower lip defects

Such abnormalities are discussed below in detail

In contrast to poisoning with phenytoin or carbamazepine, nystagmus, dysarthria and ataxia are rarely noted following VPA overdose
Targeting Vascular (Endothelial) Dysfunction
