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The inhibition kinetics and molecular modeling of these compounds showed that fixing the C4 and C5 hydroxyl groups in the diaxial conformation in the substrate mimic might be a good way to inhibit SK, due to the dramatic reduction in the flexibility of two domains(1) the SB domain (residues 917 in Mt-SK) and (2) the LID domain (residues 112124 in Mt-SK)

J Pediatr 1986;109(6):984-988

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