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Compared to cagrilintide monotherapy, tirzepatide delivers roughly twice the weight loss percentage

These signal within the brain and nervous system to influence things such as mood, appetite and pain growth factors (IGF-1)

The idea that the three act synergistically is a marketing hypothesis, not validated in any human trial
Vascular alterations, such as inflammation, remodeling, stiffness, calcification, and atherosclerosis, may play a role

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