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Trimethylamine-N-Oxide promotes vascular calcification through activation of NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (nuclear factor B) signals

Additional interventions from uncontrolled studies or low-quality evidence reports include l-carnitine, branched-chain amino acids, zinc, and muscle relaxants (baclofen, methocarbamol, orphenadrine, and eperisone hydrochloride)

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Omega-3s: You can find brain-critical omega-3 fatty acids in supplements, as well as food