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In diabetes, impaired skeletal muscle glycogen synthase activity may disrupt UDPG clearance (Majer et al., 1996), while glutamine metabolism, which possesses UDPG-lowering potential, is itself dysregulated (Petrus et al., 2020
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Kaufman and Diamond, Figure 2 Interference With the Prion-Like Spread of -Syn Ongoing research seeks to identify disease-modifying agents for PD that will restrict templated conformation changes and transcellular propagation of pathological -syn

doi: 10.3389/fmicb.2023.1238800 117 MorimotoTKobayashiTKakiuchiTEsakiMTsukamotoMYoshiharaTet al

It sits at the investigational end of the peptide spectrum
