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Furthermore, the intestinal mucosa of rats that received APO + MTX revealed weak positive immunological staining for cleaved caspase-3 (Mansoury et al

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The technique is learnable, but the decisions around it (do you actually need it, what dose, how often, and is something else being missed) are medical judgements, and getting them wrong carries real cost
This effect is mediated by a reduction in the synthesis of prostaglandins, which are cell-signaling molecules derived from the omega-6 fatty acid arachidonic acid via the action of the cyclooxygenase enzymes (Downie 1991

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