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[PUBMED Abstract] Pullen J, Boyett J, Shuster J, et al.: Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study

173 , 174 Targeting CD39 and CD73 in combination could be a strategy to reduce levels of ADO that drive the immunosuppressive environment, as inhibition at multiple nodes is likely to produce an additive or synergistic effect