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[DOI] [PubMed] [Google Scholar] 4.Musaogullari A, Chai Y-C: Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease

A central mechanism driving such pathological scarring is the persistent activation of the transforming growth factor-beta (TGF- )/Smad signaling pathway, which continuously stimulates fibroblasts and myofibroblasts, resulting in excessive collagen deposition and fibrotic remodeling (31, 32)

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The dual mechanism also appears to better preserve lean mass during weight loss, which is critically important during menopause when muscle preservation becomes increasingly challenging