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Choosing the Right Format The Route Question The published preclinical work used intraperitoneal injection in mice a route that approximates IV systemic exposure and is not directly available to humans

Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways

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