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Of note, mutations in subtype-defining transcription factors, including HNF1A , TCF4 , NEUROD1 and HNF4A , cause MODY [52, 53], and their cis -regulatory sites map to type 2 diabetes risk loci

It neutralizes free radicals, protects DNA and cellular structures, and helps the liver remove toxins through natural detoxification pathways

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

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However, they induce open bleeding and, when penetrating into the mid-to-lower dermis (0.5-2 mm), can activate dense nociceptor networks, presenting an infection risk and user discomfort [63]