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Specifically, insufficient VEGF signaling may disrupt the intricate balance of vasodilation and vasoconstriction, crucial for maintaining optimal blood flow to the brain regions

The later discovery of similar infiltrates in different phenotypes of MS, and the presence of specific anti-AQP4 and anti-MOG autoantibodies, in NMOSD and MOGAD, both highlighted the participation of peripheral immune cells in demyelination pathogenesis

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da Silva GB, Yamauchi MA, Bagatini MD