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In this strain, the cytosolic sensor was more oxidized compared to the wt, however not to the extent found in a glr1 strain, while the matrix sensor exhibited a steady state almost identical to the sensor expressed in the wt background

Glutathione peroxidase converts H 2 O 2 into two molecules of DDW, supporting low deuterium levels in mitochondrial water

An experimental analysis of a group of cancer cell lines with low and high GPX4 expression demonstrated that inhibiting DHODH could induce ferroptosis in tumor cells with low GPX4 expression while enhancing ferroptosis resistance in cancer cells with high GPX4 expression

doi: 10.1016/j.chemosphere.2017.08.130