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2B shows the results from those five countries (the United States [US], Italy, New Zealand, Norway, and Spain), for which at least 3 independent studies evaluated the use of APAP in babies and children under 6 years of age
doi:10.1016/S0021-9258(18)97085-7
These effectors reduce the affinity of the enzyme for pyruvate, thus limiting the flow of carbon through the PDH complex
