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Zinc is crucial to the structure and function of Cu/Zn-SOD, accounting for about 90% of total SOD, which exerts protective effects on tissues from oxidative damage (159)
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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)

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