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Physiological ROS act as signaling molecules, regulating physiological and metabolic functions and promoting cell proliferation and innate immune response (Mittler, 2017

Elevated CD47 expression on healthy RBCs promotes immunological tolerance and extends circulation duration, whereas reduced CD47 density on elderly or injured RBCs acts as a clearance signal (15, 21, 22)

doi: 10.1016/j.redox.2022.102497 [DOI] [PMC free article] [PubMed] [Google Scholar] [124].Rodrigues E, Mariutti LRB, Mercadante AZ

Continued exposure to environmental toxins, unmanaged inflammation, or nutritional deficiencies can influence how long benefits are sustained

Stage 4: Macrocytic anemia (abnormally large red blood cells) seen on laboratory testing