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Dulhanty, A

Experimental evidence from liver and lung models suggests that CB1 receptor activation promotes fibrosis through enhancement of the TGF-/Smad pathway, interaction with the renin-angiotensin system, and upregulation of profibrotic markers, such as collagen and -SMA

Gaffigan ME, Bruner DI, Wason C, et al

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Body skin is generally thicker and less sensitive than facial skin, potentially tolerating higher concentrations
