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It is defined by vitamin B 12 deficiency in the presence of sufficient dietary vitamin B 12 intake, negative Schilling test, and lack of anti-intrinsic factor antibodies.30 Clinically, it is diagnosed by exclusion of other disorders or factors causing vitamin B 12 deficiency

But topical application has inherent limitations

The micro-channels become an inoculation route for the bacteria already on the skin

Although there is wide interest among influencers and consumers in compounded peptides for the above indications, as well as for general wellness and anti-aging, it is important to understand that limited data are available regarding the safety and efficacy of these products

[DOI] [PubMed] [Google Scholar] 110.Duzel A., Vlainic J., Antunovic M., Malekinusic D., Vrdoljak B., Samara M., Gojkovic S., Krezic I., Vidovic T., Bilic Z., et al