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Issues such as biocompatibility and safety concerns, the complexity of manufacturing and quality control, optimization of drug delivery efficiency, understanding of nano-bio interface interactions, assessment of long-term side effects and cumulative toxicity, cost issues, the complexity of clinical trial design, and drug resistance are all challenges that must be faced in the clinical translation of nanomedicine

In the Y-maze barrier task, prenatal stress and THC reduced high-reward arm selection at low effort (10 cm) in males, whereas females showed reduced selection primarily after prenatal exposures to THC or THC/Stress

PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

J Phys Chem A 119(24):62326243

One notable example is the role of ATF4