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To test this, we used sulfur(VI) fluoride exchange (SuFEx)-based click chemistry transformations, in which an iminosulfur oxydifluoride group reacts with primary and secondary aliphatic amines to completion in DMSOPBS mixtures, forming sulfamides or sulfuramidimidoyl fluorides (Fig

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IFNs type I interferons PRRs pattern recognition receptors TLR Toll-like receptor RIG-I like receptor a pattern recognition receptor DENVandWNV infections have been the subject of a large body of studies that show a pivotal role for RIG-I, MDA5 and TLR3 sensors in the host defense against these viruses, leading to IFN type 1 production and expression of ISGs