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Agents that target androgen synthesis in castration-resistant prostate cancer
In addition to this, there are various factors contributing to oxidative stress in FRDA, including mitochondrial labile iron, NRF2 expression, lipid peroxidation, and Ca 2+ homeostasis, which means therapeutics may need to combat a number of these factors to overcome oxidative stress
Although many mitochondria-related mechanisms still have to be investigated, and whether they are the cause or consequence of this disorder is still unknown, the accumulating data show that the breakdown of any of the mitochondrial functions may contribute to abnormal brain development leading to ASD
doi: 10.1126/science.1160809 14 Vander HeidenMGLocasaleJWSwansonKDSharfiHHeffronGJAmador-NoguezDet al
De asemenea, tratamentul cu anticonvulsive, acid valproic, fenobarbital, fenitoina sau carbamazepina reduce nivelul carnitinei din sange
