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Alternatively, PGC-1 may mediate the expression of motor proteins in spinal cord motoneurons and thus modulate movement disorders in an animal model of PD through the stimulation of the upstream promoter of the mitochondrial fusion-associated protein Mfn2 (Mou et al., 2021

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If this phenomenon occurs, particularly when triggering factors are present, patients should be advised to avoid triggering movements and consider taking oral methylcobalamin, the active form of Vitamin B12, which acts as a neurotrophic repair agent

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