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Furthermore, as the parameters required for afferent vagal nerve activation in the ear and neck differ from those required for implantable vagal nerve activation, different stimulations are required to screen for optimal parameters for taVNS and tcVNS and iVNS before assessing the efficacy

Inhibitors of HIF-1 translation Although the nature of the regulating HIF-1 protein translation is still poorly understood, several agents have been progressed that target the rate of HIF-1 protein synthesis, including but not limited to inhibitors of topoisomerase I and II, receptor tyrosine kinase, cyclin-dependent kinase, oncogenic pathways, and microtubule disrupting agents

In other words, some research findings related to microecological preparations are contradictory

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Camenga D , Kong G