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While human risk appears minimal based on post-marketing surveillance, the contraindication remains

Source: Traverso, N., Ricciarelli, R., Nitti, M., et al

26 B12 present in food products requires gastric enzymes such as pepsin and stomach acid to detach it from protein, while supplemental forms of B12 are typically in an unbound state and do not require this process for absorption

Selank Purported Benefits: Reduction of anxiety Improved memory and learning Potential Risks and Complications: Neurological Effects: Without proper studies, the impact on brain chemistry is unknown, potentially worsening anxiety or depression

Besides, goiter may be experimentally induced in animals exposed to goitrogenic substances, like perchlorate or thiocyanates, which block iodine uptake in the thyroid gland, causing a similar compensatory rise in secretion of TSH and hyperplasia of thyroid cells (Nourani and Sadr 2023)