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Description
It is also needed to stimulate the production and activity of natural killer (NK) cells

This event implies that the pathogenesis of IRI is at least partly attributable to the effect of ROS on the TLR4 activation

Furthermore, in sepsis models, BAM15 polarizes macrophages toward anti-inflammatory phenotypes and reduces pro-inflammatory cytokine production via AMPK-SIRT1-PGC1 axis activation (Dang et al., 2021)

Presently, there are studies which have evaluated the effectiveness of L-citrulline or citrulline malate after periods of 7 and 16 days

[102] Selma MV, Beltrn D, Luna MC, et al
