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5.1 ApoE and Parkinsons disease (PD) PD is the second most prevalent neurodegenerative disorders, characterized by the accumulation of protein aggregates known as Lewy Bodies (LBs) within brain cells
This implies that the initial step in this specific pathologic process is the presynaptic reduction of GABA synthesis, followed by a secondary, compensatory reduction of reuptake by means of GAT-1 and by compensatory upregulation of postsynaptic GABA receptors (1, 18, 86)
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Their findings suggest that the oxygen atom on quercetins B ring is the primary site of electron density change, underpinning its ROS-scavenging activity
