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Its a normal and natural function, but an excess of prostaglandin can result in an increase in pain-causing inflammation

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[32] Drug interactions [edit] Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together

If the digestion remains incomplete at the highest enzyme-to-substrate ratios and longest time points, consider reengineering the protease cleavage site to include several glycines between the GST moiety and the target protein to decrease the likelihood of steric hindrance interfering with the cleavage (19, 20)