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Disruption of this inhibitory interaction allows increased nitric oxide production, which is relevant to endothelial signaling and vascular responsiveness in experimental systems [3]

Its a start more data on any potential longer-term effects would of course lend reassurance

Nicholson JK, Holmes E, Kinross J, et al

Potential Side Effects and Limited Human Data While preclinical studies have not shown significant toxicity at standard doses, the research in humans is still in its early stages

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