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Neurology 75 , 9971002 (2010)

Viability assay AML cells were plated at 20x10 4 /mL in 100 l of 10% FBSsupplemented RPMI prior to the addition of compounds

A plausible mechanism for a more substantial selective effect of mTORC1 on protein synthesis in T cells involves the pathways that couple mTORC1 to the translational control of 5' terminal oligopyrimidine tract (5'TOP) mRNAs, which include mRNAs encoding ribosomes and translation factors

These products also activate inflammatory pathways in IBD, inducing the expression of proinflammatory cytokines, chemokines, and adhesion molecules (39)

Moreover, Mn overload contributes to various forms of toxicity through several mechanisms