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Retatrutide is an investigational peptide compound that acts as a triple agonist, targeting three hormone receptors simultaneously: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Figure 2 Metabolic adaptations during lymphatic metastasis Metabolic reprogramming supports the diverse energetic and proliferative demands of cancer cells but also creates unique metabolic shifts that can influence disease progression and therapeutic targets

Most cases have shown positive expression of proliferating cell nuclear antigen (PCNA) in basal, suprabasal, and superficial layers (Keshav and Narayanappa, 2015)