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Although guidelines exist for managing specific adverse effects, such as peripheral neuropathy, comprehensive approaches for addressing the full spectrum of long-term chemotherapy-induced toxicities remain limited [16]

In cancer cells, mitochondrial function is not entirely impaired, and oxidative phosphorylation and TCA are still functioning [114]

Handle under standard laboratory aseptic technique with PPE per institutional biosafety guidelines

doi:10.1007/s00702-019-02083-z Mansour A, Hariri E, Shelh S, Irani R, Mroueh M