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In most human GST isozymes the amino acid acting as the proton acceptor is a tyrosine, the phenol function of which is itself deprotonated by a neighboring strongly basic amino acid residue
Finally, L-carnitine is involved in boosting the cellular antioxidant defense system by enhancing the action of the cells naturally produced antioxidants (such as glutathione and vitamin E) through regeneration and recycling [22,23]
This oxidative milieu can damage cellular components, including enzymes critical for energy metabolism
In terms of hormonal regulation, vitamin D can also antagonize the proliferative effects of E and progesterone in uterine fibroid tissue
