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Importantly, serum B12 levels can be misleadingly normal or even elevated in chronic liver disease due to increased levels of binding proteins (such as haptocorrin) and reduced clearance, meaning that total B12 measurements may not accurately reflect tissue B12 status or functional deficiency

also reported that lactate enhances HMGB1 acetylation via GPR81 and Hippo/YAP mediated pathways

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Preclinical and clinical research studies have examined its effects on gastric emptying, glucagon secretion, and food intake

Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation