glutathione synthetase deficiency genereview SYNTHESIS Multiple congenital anomalies in two

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This step is catalyzed by the vitamin B6 coenzyme pyridoxal phosphate, in reaction of homocysteine with serine to form cystathionine

The removal of NCKAP1 and other WRC proteins weakens disulfide stress, whereas the excessive expression of constitutively activated Rac stimulates disulfidptosis in a WRC-dependent manner (Liu et al., 2023a)