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The mechanisms underlying diabetes-related cardiac fibrosis can be attributed to a combination of factors, including oxidative stress, inflammation, increased production of advanced glycation end products (AGEs), and increased expression of growth factors (1012)

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide, first identified in mammalian brain tissue in the 1970s

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ABCG2 cysteine residues Cys592 and Cys608 formed intramolecular disulfide bonds, regulating substrate specificity, whereas Cys603 and Cys608 created intermolecular disulfide bonds, determining plasma membrane localization (Wakabayashi et al., 2006)