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Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS

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When symptoms do occur, they may include 7,46,47 : Debilitating fatigue Itching and numbness Headaches Muscle cramps Weight loss Sleep disturbances Lack of appetite Nausea and vomiting Shortness of breath Seizures Edema (swelling) of the extremities CKD is often discovered in people who do not have significant symptoms when they either attend their yearly physical and undergo lab testing or have blood work done for other reasons

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It exerts a protective effect by scavenging peroxynitrite and preventing the release of AIF and EndoG from mitochondria and subsequent nuclear DNA breakage (Du et al., 2015)